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AssigneeThe General Hospital Corporation
InventorsWilliam Lee, Jeffrey R. Morgan, Martin L. Yarmush
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The invention is based on the discovery that certain membranes, which include side chains or molecular “brushes” having, for example, tertiary amino functional groups, can be used as highly effective filters to capture viruses/virus particles from liquids without removal of proteins. New methods based on this discovery include removing viruses from liquids such as blood or plasma, removing viruses from pharmaceuticals, concentrating and/or purifying viruses, e.g., for use in gene therapy, and producing recombinant viruses in new bioreactors. The invention also includes new methods of therapy or adjunct therapy for viral infections, in which a patient's blood or plasma is filtered through the membranes to remove viruses to reduce the viral load. The invention also includes new bioreactors and viral filters containing the membranes.
A method of removing viruses from the blood of an individual having a viral infection, the method comprising:
A device for removing viruses from a liquid sample, the device comprising a membrane engrafted with polymeric side chains, each side chain having one or more positively charged functional groups that interact with viruses, the polymeric side chains each having one functional group per repeat unit, each functional group consisting of a single secondary, tertiary, or quaternary amine, and having a single positive charge at physiological pH, wherein the membrane has a nominal pore size between 20 nm and 1000 nm.
A method of isolating virus particles, the method comprising
A device for isolating virus particles comprising:
Dependencies are inferred from the claim text.