Process for preparing crystalline 3-chloromethyl-3-cephem derivatives
AssigneeNippon Chemical Industrial Co., Ltd.
InventorsNobuo Matsumoto, Hiroshi Kawakabe, Yasuko Manabe
Life of this patent
Estimating the term…
Abstract
A chlorinated azetidinone derivative expressed by Formula (1) and an alcoholate are allowed to react in a solvent containing at least one of alcohols and an ether at a pH of 8 or less. Thus a 3-chloromethyl-3-cephem derivative expressed by Formula (2) is prepared. In the formulas, R1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic residue, and R2 and R3 each represent a substituted or unsubstituted aromatic hydrocarbon group.
Claims14
A process for preparing a crystalline 3-chloromethyl-3-cephem derivative, comprising a reaction step of performing a reaction of a chlorinated azetidinone derivative with an alcoholate, in a solvent containing at least one alcohol, and at a pH of 8 or less,
- wherein the chlorinated azetidinone derivative is expressed by Chemical Formula (1):
- where R1 represents one selected from the group consisting of substituted and unsubstituted aryl groups and substituted and unsubstituted heterocyclic residues, and R2 and R3 each represent one selected from the group consisting of substituted and unsubstituted aromatic hydrocarbon groups, and
- wherein the 3-chloromethyl-3-cephem derivative is expressed by Chemical Formula (2):
- where R2 and R3 each represent one selected from the group consisting of substituted and unsubstituted aromatic hydrocarbon groups.
A process for preparing a crystalline 3-chloromethyl-3-cephem derivative, comprising the a reaction step of performing a reaction of a chlorinated azetidinone derivative with an alcoholate, in a solvent containing at least one alcohol and at least one ether, and at a pH of 8 or less,
- wherein the chlorinated azetidinone derivative is expressed by Chemical Formula (1):
- where R1 represents one selected from the group consisting of substituted and unsubstituted aryl groups and substituted and unsubstituted heterocyclic residues, and R2 and R3 each represent one selected from the group consisting of substituted and unsubstituted aromatic hydrocarbon groups, and
- wherein the 3-chloromethyl-3-cephem derivative is expressed by Chemical Formula (2):
- where R2 and R3 each represent one selected from the group consisting of substituted and unsubstituted aromatic hydrocarbon groups.
Dependencies are inferred from the claim text.