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US 7,157,570 B2Granted
Human ribonucleotide reductase M2 subunit
OwnerYun Yeninventor
Life of this patent
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Abstract
An isolated nucleic acid containing a human ribonucleotide reductase M2 subunit promoter sequence or genomic sequence. Also disclosed are methods of determining whether a subject is suffering from or at risk for developing a cell proliferation-associated disorder, identifying a compound for treating a cell proliferation-associated disorder, treating a cell proliferation-associated disorder, and developing a procedure for treating a cell proliferation-associated disorder.
Claims12
A recombinant isolated nucleic acid comprising:
- a hRPM2 promoter sequence consisting of SEQ ID NO:2, and
- a heterologous nucleotide sequence encoding a transcript,
- wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
A recombinant isolated nucleic acid comprising:
- a hRPM2 promoter sequence consisting of SEQ ID NO:3, and
- a heterologous nucleotide sequence encoding a transcript,
- wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
A recombinant isolated nucleic acid comprising:
- a hRPM2 promoter sequence consisting of SEQ ID NO:4, and
- a heterologous nucleotide sequence encoding a transcript,
- wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
A recombinant isolated nucleic acid comprising:
- a hRPM2 promoter sequence consisting of SEQ ID NO:1, and
- a heterologous nucleotide sequence encoding a transcript,
- wherein the promoter sequence is operably linked to the heterologous nucleotide sequence.
Dependencies are inferred from the claim text.