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US 7,157,492 B2Granted
Dibenzo chromene derivatives and their use as ERβ selective ligands
AssigneeWyeth
InventorsRichard Eric Mewshaw, Richard James Edsall, Jr.
Life of this patent
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Abstract
This invention provides estrogen receptor modulators of formula I, having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the specification.
Claims9
A compound of the formula
- wherein
- R1, R2, R3, R5, R6, R7 and R8 are each, independently, selected from hydrogen, hydroxyl, C1–C6 alkyl, C1–C6 alkoxy or halogen;
- R4 is hydrogen, C1–C6 alkyl, halogen, C1–C6 alkoxy, —CN, C2–C8 alkenyl, —CHO, aryl, furyl, thienyl, pyrimidinyl or pyridinyl;
- provided that at least one of R1–R8 is other than H;
- or a pharmaceutically acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.