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US 7,157,491 B2Granted
Aryl-carbaldehyde oxime derivatives and their use as estrogenic agents
AssigneeWyeth
InventorsRichard Eric Mewshaw, Stephen Todd Cohn
Life of this patent
Estimating the term…
Abstract
This invention provides estrogen receptor modulators having the structure where R1–R5 are as defined in the specification; or a pharmaceutically acceptable salt thereof.
Claims10
A compound of the formula:
- wherein:
- R1 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R2 and R3, together, form a fused aryl or heteroaryl ring;
- R4 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R5 is hydrogen, lower alkyl, or —C(O)R6;
- and
- R6 is lower alkyl;
- or a pharmaceutically acceptable salt thereof.
5 more elements
A pharmaceutical composition comprising:
- a compound of the formula:
- wherein:
- R1 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R2 and R3, together, form a fused aryl or heteroaryl ring;
- R4 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R5 is hydrogen, lower alkyl, or —C(O)R6;
- and
- R6 is lower alkyl;
- or a pharmaceutically acceptable salt thereof;
- and
- a pharmaceutically acceptable carrier.
8 more elements
A method of inhibiting osteoporosis in a mammal in need thereof, comprising providing to said mammal an effective amount of a compound of the formula:
- wherein:
- R1 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R2 and R3, together, form a fused aryl or heteroaryl ring;
- R4 is hydrogen, halogen, lower alkyl, CN, or lower alkoxy;
- R5 is hydrogen, lower alkyl, or —C(O)R6;
- and
- R6 is lower alkyl;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.