Pharmaceutical formulation containing irritant
AssigneeEuro-Celtique S.A.
InventorRichard Sackler
Life of this patent
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Abstract
Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.
Claims43
An oral dosage form comprising:
- a therapeutically effective amount of an opioid analgesic;
- and
- an effective amount of a sequestered irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering, wherein said sequestered irritant is in the form of multiparticulates individually coated with a material that substantially prevents release of the irritant.
A method of preparing a pharmaceutical dosage form comprising combining a therapeutically effective amount of an opioid analgesic in a dosage form with an effective amount of a sequestered irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering wherein said sequestered irritant is in the form of multiparticulates individually coated with a material that substantially prevents release of the irritant.
A method of preparing a pharmaceutical dosage form comprising combining an opioid analgesic in a dosage form with an effective amount of a sequestered irritant to impart an irritating sensation to an abuser upon administration, of said dosage form after tampering, wherein said sequestered irritant is in a matrix comprising a sequestering material that substantially prevents release of the irritant.
An oral dosage form comprising:
- a therapeutically effective amount of an opioid analgesic;
- and an effective amount of a sequestered irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering, wherein said sequestered irritant is in a matrix comprising a sequestering material that substantially prevents release of the irritant.
Dependencies are inferred from the claim text.