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US 7,153,966 B2Granted
Preparation of oxycodone
AssigneeJohnson Matthey Public Limited Company
InventorsMichael Lawrence Casner, Jen-Sen Dung, Erno M. Keskeny, Jin Luo
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Abstract
A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequently b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour.
Claims12
A process for preparing oxycodone or an oxycodone salt, comprising the steps of:
- a) preparing a mixture comprising oxycodone and a solvent, adjusting the pH of the mixture to less than 6 and heating the mixture at the temperature of at least 55° C for a period of at least 1 hour;
- and subsequently
- b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour.
Dependencies are inferred from the claim text.