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US 7,153,660 B2Granted
Non-invasive enzyme screen for tissue remodelling-associated conditions
AssigneeChildren's Medical Center Corporation
InventorsMarsha A. Moses, Li Yan
Life of this patent
Estimating the term…
Abstract
Methods and kits for diagnosing the presence of and prognosing the appearance of tissue remodelling-associated conditions, involving the presence of enzyme complexes in a biological sample, are disclosed. In particular, the method pertains to diagnosing the presence of or prognosing appearance of metastatic cancer by the identification of high molecular weight enzyme complexes comprising MMPs.
Claims10
A non-invasive method for facilitating the diagnosis of a subject for a tissue remodeling-associated condition, comprising:
- obtaining a urine sample from a subject;
- contacting the urine sample with an antibody specifically reactive with NGAL to detect an MMP-9/NGAL complex in the urine sample;
- wherein the presence of the MMP-9/NGAL complex indicates the presence of a tissue remodeling-associated condition, thereby facilitating the diagnosis of the subject for a tissue remodeling-associated condition.
Dependencies are inferred from the claim text.