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AssigneeRegeneration Technologies, Inc.
InventorsJohn F. Wironen, Chris Seid, Rebecca Jaw, Thien Doan, Gregg Ritter, Russell S. Donda
Estimating the term…
Disclosed herein are novel injectable, biocompatible compositions, preferably, comprising a combination of particulate, processed tissue and a carrier. Specifically disclosed are compositions comprising acellular, pulverized dermis combined with at least one glycosaminoglycan and/or gelatin. The subject compositions provide for improved retention of the composition at the site of implantation. Also disclosed are medical applications using the disclosed compositions, such as cosmetic enhancement or filling in of voids due to abnormalities, injuries, surgery, or aging. In addition, kits comprising at least one container of a freeze-dried, particulate tissue and at least one container of a glycosaminoglycan, or crude platelet extract and used thereof as a wound treatment/dressing, are disclosed.
An implantable composition comprising an admixture of a carrier and acellular, pulverized dermis tissue, wherein said dermis tissue is allogenic or xenogenic, or both, wherein said carrier is a gelatin and wherein said gelatin comprises about 10 to about 30 percent, by weight, of said composition.
An implantable composition comprising an admixture of a carrier and acellular, pulverized dermis tissue, wherein said dermis tissue is allogenic or xenogenic, or both, wherein said carrier is hyaluronic acid, and said hyaluronic acid comprising about 0.5 to about 5 percent of said composition.
A kit comprising a first syringe containing an amount of a reconstitution fluid and a second syringe comprising an admixture of freeze-dried acellular, pulverized dermis, gelatin and a carrier selected from the group consisting of hyaluronic acid and chondroitin sulfate, wherein when the contents of the first syringe and the second syringe are combined to provide a reconstituted composition, the gelatin comprises 10% to 30% by weight of reconstituted composition, the hyaluronic acid comprises 0.5 to 5 percent by weight of said reconstituted composition and the chondroitin sulfate comprises 1% to 30% by weight of said reconstituted composition.
A kit comprising at least one container containing an amount of acellular, particulate dermis and at least one container comprising an aqueous carrier solution, wherein said aqueous carrier solution comprises at least one glycosaminoglycan selected from the group consisting of hyaluronic acid, chondroitin sulfate and a mixture thereof, wherein said hyaluronic acid comprises 0.5 to 5 percent by weight of said solution, and wherein said chondroitin sulfate comprises 1 percent to 15 percent by weight of said solution.
A piece of acellular, dermis infused with a solution comprising one or more glycosaminoglycans, wherein said one or more glycosaminoglycans are selected from the group consisting of hyaluronic acid and chondroitin sulfate, wherein said hyaluronic acid comprises 0.5 to 5 percent by weight of said infused dermis, and wherein said chondroitin sulfate comprises 1 percent to 15 percent by weight of said infused dermis.
A kit comprising a first container comprising freeze-dried, pulverized dermis and a second container comprising a reconstitution solution, wherein said reconstitution solution comprises hyaluronic acid at a concentration of from about 0.5 percent to about 5 percent by weight of said solution, or chondroitin sulfate at a concentration of from about 1 percent to about 15 percent by weight of said solution, or a combination thereof.
Dependencies are inferred from the claim text.