US 7,148,209 B2 · Composition and method for the repair and regeneration of cartilage and other tissues

Abstract

The present invention relates to a new method for repairing human or animal tissues such as cartilage, meniscus, ligament, tendon, bone, skin, cornea, periodontal tissues, abscesses, resected tumors, and ulcers. The method comprises the step of introducing into the tissue a temperature-dependent polymer gel composition such that the composition adhere to the tissue and promote support for cell proliferation for repairing the tissue. Other than a polymer, the composition preferably comprises a blood component such as whole blood, processed blood, venous blood, arterial blood, blood from bone, blood from bone-marrow, bone marrow, umbilical cord blood, placenta blood, erythrocytes, leukocytes, monocytes, platelets, fibrinogen, thrombin and platelet rich plasma. The present invention also relates to a new composition to be used with the method of the present invention.

Claims44

Dependent claims

A method for repair and/or regeneration in cartilaginous tissue comprising administering at a site of the cartilaginous tissue in need of repair an effective amount of a polymer composition comprising:

a solution of a polymer;
and
blood,
wherein the polymer includes at least one selected from the group consisting of a polysaccharide, a protein, and a polyamino acid, and further wherein when the polymer is combined with blood the polymer composition is converted into a non-liquid state in time or upon heating such that the polymer compositions when placed at the site in need of repair, the polymer composition will adhere to the site in need of repair to effect reconstruction or bulking of the tissue and/or regeneration thereof.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

11/031,325Filed 7 Jan 2005 · continuation

Priority

29 Jun 2000

Published

US 2006/0029578 A19 Feb 2006

Granted

12 Dec 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification29 codes

A61L 27/3804
Containing added animal cells: characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/06
Medicinal preparations characterised by special physical form: ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Family

Application60/214,717Us provisional application · filed 29 Jun 2000

Application09/896,912Parent of this continuation · filed 29 Jun 2001

US 2006/0029578 A1Pre-grant publication · published 9 Feb 2006

US 2002/0082220 A1Published application

US 7,148,209 B2This patent

From the US filing history. Foreign family members aren’t listed.

Composition and method for the repair and regeneration of cartilage and other tissues

Life of this patent

Composition and method for the repair and regeneration of cartilage and other tissues

Life of this patent

Abstract

Claims44