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US 7,147,687 B2Granted
Non-alloying core shell nanoparticles
AssigneeNanosphere, Inc.
InventorsChad A. Mirkin, Yun-Wei Cao, Rongchao Jin
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Abstract
The present invention relates composite core/shell nanoparticles and a two-step method for their preparation. The present invention further relates to biomolecule-core/shell nanoparticle conjugates and methods for their preparation. The invention also relates to methods of detection of biomolecules comprising the biomolecule-core/shell nanoparticle conjugates.
Claims14
A method for preparing core/shell nanoparticles comprising the steps of:
- (a) providing metal-containing cores;
- (b) treating the metal-containing cores simultaneously with a solution comprising a gold salt and a solution comprising a reducing agent so as to form a reaction mixture having a gold salt concentration of about 2 uM and generate a non-alloying gold shell surrounding the nanoparticle cores to produce core/shell nanoparticles;
- and
- (c) isolating the core/shell nanoparticles.
1 more element
Dependencies are inferred from the claim text.