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US 7,144,984 B2Granted
Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
AssigneeThe Scripps Research Institute
InventorsPaul Schimmel, Keisuke Wakasugi
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Abstract
Compositions comprising tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed.
Claims4
An isolated angiogenic truncated tyrosyl-tRNA synthetase polypeptide comprising a Rossmann fold nucleotide binding domain, wherein the isolated polypeptide is capable of regulating angiogenic vascular endothelial cell function;
- wherein the polypeptide is selected from the group consisting of:
- a polypeptide consisting essentially of amino acid residues 1–364 of SEQ ID NO:
- 2,
- a polypeptide consisting of amino acid residues 1–343 of SEQ ID NO:
- 2,
- a dimer of a polypeptide consisting essentially of amino acid residues 1–364 of SEQ ID NO:
- 2.
4 more elements
Dependencies are inferred from the claim text.