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US 7,144,903 B2Granted
CCR4 antagonists
AssigneeAmgen Inc.
InventorsTassie Collins, Hossen Mahmud, Jonathan Houze, Alan Xi Huang, Julio C. Medina, Xuemei Wang, Feng Xu, Qingge Xu, Liusheng Zhu
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Abstract
Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.
Claims44
A compound having the formula (I):
- or a pharmaceutically acceptable salt or prodrug thereof, wherein
- W is substituted indolyl;
- X is S;
- Y is N(R5);
- Z is N;
- R1 is unsubstituted (C1–C8)alkyl or (C1–C8)alkyl substituted with NR′R″ in which R′ and R″ are independently selected from the group consisting of aryl (C1–C4)alkyl and unsubstituted (C1–C8)alkyl, and wherein, optionally, R′ and R″ are combined with the nitrogen atom to which they are attached to form a 5-, 6- or 7-membered ring;
- R2 is H or (C1–C8)alkyl;
- and
- optionally, R1 and R2 combine to form a 5- to 8-membered ring;
- and
- R5 is selected from the group consisting of H, (C1–C8)alkyl, heteroatkyl, aryl and heteroaryl.
8 more elements
Dependencies are inferred from the claim text.