Marine actinomycete taxon for drug and fermentation product discovery
AssigneeThe Regents of the University of California
InventorsWilliam Fenical, Paul R. Jensen, Tracy J. Mincer
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Abstract
The invention is the discovery of an actinomycete genus, given the name Salinospora gen. nov., that displays an obligate requirement of seawater (Na+) for growth and unique 16S rRNA signature nucleotides. The invention is also the use of the genus for the production and discovery of active biomolecules such as pharmaceutical agents, agrichemicals, immunomodifiers, enzymes and enzyme inhibitors.
Claims9
An isolated marine actinomycete having an obligate requirement of sodium for growth, wherein the marine actinomycete is a strain of Salinospora comprising 16S rRNAs SEQ ID NO:4 or 5.
An isolated strain of Salinospora having an obligate requirement of sodium for growth, wherein the strain of Salinospora is a strain of Salinospora comprising 16S rRNAs SEQ ID NO:4 or 5 and signature nucleotides therein, wherein the signature nucleotides are numbered and identified in accordance to the E.coli 16S rRNA sequence, wherein a uridine or cytosine at position 207 is an adenosine;
- an adenosine or guanine at position 366 is a cytosine;
- an adenosine or guanine at position 467 is a uracil;
- an adenosine at position 468 is a uracil;
- and adenosine at position 1456 is a guanine.
An isolated strain of Salinospora having an obligate requirement of sodium for growth, wherein the strain of Salinospora is a strain of Salinospora comprising a 16S rRNA and signature nucleotides therein, wherein the signature nucleotides are numbered and identified in accordance to the E.coli 16S rRNA sequence, wherein a uridine or cytosine at position 207 is an adenosine;
- an adenosine or guanine at position 366 is a cytosine;
- an adenosine or guanine at position 467 is a uracil;
- an adenosine at position 468 is a uracil;
- and adenosine at position 1456 is a guanine.
Dependencies are inferred from the claim text.