Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

A compound having the formula,

• or a pharmaceutically acceptable salt, solvate, prodrug or stereoisomer thereof.

A compound having the formula,

• wherein R7 is NHSO2(C1-4alkyl), or a pharmaceutically acceptable salt, solvate, prodrug, or stereoisomer thereof.

A compound having the formula,

A compound having the formula,

A method for treating a condition or disorder comprising administering to a mammalian species in need thereof a therapeutically effective amount of at least one compound of the following formula:

• wherein R7 is NHSO2(C1-4alkyl);
• or a pharmaceutically acceptable salt, solvate, prodrug, or stereoisomer thereof;
• wherein said condition or disorder is selected from the group consisting of benign prostate hypertrophia, adenomas and neoplasies of the prostate, heart disease, hirsutism, acne, hyperpilosity, seborrhea, endometriosis, polycystic ovary syndrome, androgenic alopecia, hypogonadism, osteoporosis, suppressing spermatogenisis, libido, cachexia, anorexia, inhibition of muscular atrophy in ambulatory patients, androgen supplementation for age related decreased testosterone levels in men, prostate cancer, breast cancer, endometrial cancer, hot flashes, vaginal dryness, menopause, amenorrhea, dysmenorrhea, contraception, pregnancy termination, cancers containing the progesterone receptor, endometriosis, cachexia, menopause, cyclesynchrony, meniginoma, fibroids, labor induction, psychotic disorders, drug dependence, non-insulin dependent Diabetes Mellitus, dopamine receptor mediated disorders, congestive heart failure, and disregulation of cholesterol homeostasis.