US 7,141,382 B1 · Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality

Abstract

The present disclosure concerns methods of detecting a molecule, interleukin 18, in a sample, and using the detection of IL-18 to predict a condition. In a particular embodiment, the present invention concerns methods of detecting interleukin 18, in a sample, preferably prior to the increase in serum creatinine in a subject predisposed to a condition. In certain embodiments, the methods may comprise obtaining a sample from a subject such as a urine or blood sample and analyzing the sample for the presence or absence of IL-18 to predict a condition for example acute renal failure or organ transplant failure. In another embodiment, the methods may comprise analyzing a sample from a subject for the presence of IL-18 and applying information obtained from analyzing the presence of IL-18 to determine a treatment for a medical condition of the subject.

Claims11

Dependent claims

A method for diagnosing acute renal failure in a subject comprising:

identifying a subject having acute respiratory distress syndrome (ARDS) or acute lung injury (ALI) not currently diagnosed with acute renal failure (ARF);
measuring the concentration of serum creatinine in the subject;
obtaining a urine sample from the subject prior to elevated serum creatinine in the subject, wherein elevated serum creatinine is indicated by a 50% increase of serum creatinine concentration above a baseline concentration of serum creatinine in the subject wherein the baseline serum creatinine is equal to or less than 1.2 mg/dl;
assessing the concentration of interleukin 18 (IL-18) protein in the sample;
and
diagnosing the presence of ARF in the subject prior to elevated serum creatinine concentration based on an increased concentration of IL-18 protein in the sample relative to a normal control subject.

3 more elements

Dependencies are inferred from the claim text.

Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality

Life of this patent

Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality

Life of this patent

Abstract

Claims11