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US 7,141,210 B2Granted
Apparatus and method for a nanocalorimeter for detecting chemical reactions
AssigneePalo Alto Research Center Incorporated
InventorsAlan G. Bell, Richard H. Bruce, Scott A. Elrod, Eric Peeters, Francisco E. Torres
Life of this patent
Estimating the term…
Abstract
A nanocalorimeter array for detecting chemical reactions includes at least one thermal isolation region residing on a substrate. Each thermal isolation region includes at least one thermal equilibration region, within which resides a thermal measurement device connected to detection electronics.
Claims28
A nanocalorimeter array for detecting chemical reactions the nanocalorimeter array comprising:
- a substrate;
- at least two thermal isolation regions residing on said substrate, wherein said thermal isolation regions comprises a material having low thermal conductivity;
- at least one reference region and at least one measurement region residing within said thermal isolation regions, wherein said at least one reference region is operatively associated with said at least one measurement region, and wherein said reference region receives reference reagents;
- at least two drop merging electrodes residing within each said reference region and each said measurement region for mixing solutions on the nanocalorimeter array, wherein drops of said solutions are merged by application of a voltage to the electrodes;
- at least one thermal equilibration region positioned within each said reference region and each said measurement region adjacent to and mechanically supported by said thermal isolation regions, wherein said drops of said solutions are brought to thermal equilibrium before being merged;
- and
- at least one thermal measurement device residing as a layer within each said at least one thermal equilibration region, wherein said thermal measurement device is connected to detection electronics.
4 more elements
A nanocalorimeter array for detecting chemical reactions the nanocalorimeter array comprising:
- a substrate;
- at least two thermal isolation regions residing on said substrate, wherein said thermal isolation regions comprises a material having low thermal conductivity;
- at least one reference region and at least one measurement region residing within said thermal isolation regions, wherein said at least one reference region is operatively associated with said at least one measurement region, and wherein said reference region receives reference reagents;
- at least one thermal equilibration region positioned within each said reference region and each said measurement region adjacent to and mechanically supported by said thermal isolation regions, wherein drops of said solutions are brought to thermal equilibrium before being merged;
- and
- at least one thermal measurement device residing as a layer within each said at least one thermal equilibration region, wherein said thermal measurement device is connected to detection electronics, and wherein said detection electronics are detachably connected to the nanocalorimeter array.
3 more elements
Dependencies are inferred from the claim text.