Transdermal drug delivery device, method of making same and method of using same
AssigneeAltea Therapeutics Corporation
InventorsJonathan Eppstein, Stuart McRae, Joseph Papp
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Abstract
A transdermal drug delivery device for forming a micropore in a tissue membrane of an animal comprising a substrate and a porator that is located on or within the substrate. The porator is constructed of a material that is destroyed upon forming the micropore. The transdermal drug delivery device also comprises at least one reservoir and a controller for controlling the formation of said micropore by the porator and destroying the porator after the formation of the micropore.
Claims26
A transderrnal drug delivery device for forming a micropore in a tissue membrane of an animal, comprising:
- a) a tissue interface layer comprising:
- i) a substrate;
- and
- ii) at least one porator, wherein said porator is located on or within said substrate and said porator is constructed of a material in which said porator is destroyed upon forming said micropore;
- b) at least one reservoir in communication with said tissue interface layer;
- and
- c) a controller for controlling the formation of said micropore by said at least one porator, wherein the controller is configured to destroy said porator substantially following the formation of said micropore.
A method of forming at least one micropore in a tissue membrane of an animal composing:
- a) providing a poration device, said poration device including:
- i) a tissue interface layer comprising:
- A) a substrate;
- and
- B) at least one porator, wherein said porator is located on or within said substrate and said porator is constructed of a material in which said porator is destroyed upon forming said micropore;
- ii) at least one reservoir in communication with said tissue interface layer;
- and
- iii) a controller for controlling the formation of said micropore by said at least one porator;
- b) contacting said poration device with said tissue membrane;
- c) providing a thermal or electrical pulse to said at least one porator by way of said controller, thereby forming said at least one micropore in said tissue membrane;
- and
- d) destroying said at least one porator after forming said at least one micropore by sustaining said thermal or electrical pulse for a duration sufficient to destroy said at least one porator.
Dependencies are inferred from the claim text.