Sugar modified oligonucleotides
AssigneeIsis Pharmaceuticals, Inc.
InventorsPhillip Dan Cook, Andrew Mamoru Kawasaki
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Abstract
Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
Claims6
A mixed sequence oligonucleotide or oligonucleotide analog including more than one 2′-modified 2′-deoxyfuranosyl moiety wherein said modification comprises substitution by halo, azido, amino, alkoxy, thioalkoxy, alkylamino, or alkyl, and wherein one of said 2′-modified 2′-deoxyfuranosyl moieties is different from another of said 2′-modified 2′-deoxyfuranosyl moieties.
Dependencies are inferred from the claim text.