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US 7,138,501 B2Granted
Antibodies that immunospecifically bind BLyS
AssigneeHuman Genome Sciences, Inc.
InventorsSteven M. Ruben, Gil H. Choi, Tristan Vaughan, David Hilbert
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AssigneeHuman Genome Sciences, Inc.
InventorsSteven M. Ruben, Gil H. Choi, Tristan Vaughan, David Hilbert
Estimating the term…
The present invention relates to antibodies and related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention also relates to methods and compositions for detecting or diagnosing a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate function of B Lymphocyte Stimulator comprising antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B Lymphocyte Stimulator expression or inappropriate B Lymphocyte Stimulator function comprising administering to an animal an effective amount of one or more antibodies or fragments or variants thereof or related molecules that immunospecifically bind to B Lymphocyte Stimulator.
An isolated antibody that immunospecifically binds B Lymphocyte Stimulator protein wherein said antibody comprises a first amino acid sequence at least 85% identical to amino acid residues 1–123 of SEQ ID NO:327 and a second amino acid sequence at least 85% identical to amino acid residues 141–249 of SEQ ID NO:327 and wherein said B Lymphocyte Stimulator protein is selected from the group consisting of:
An isolated antibody that immunospecifically binds B Lymphocyte Stimulator protein wherein said antibody comprises amino acid residues 1–123 of SEQ ID NO:
An antibody purified from the cell line contained in American Type Culture Collection Deposit Number PTA-3239.
An antibody purified from the cell line contained in American Type Culture Collection Deposit Number PTA-3240.
An isolated antibody that immunospecifically binds B Lymphocyte Stimulator protein wherein said antibody comprises amino acid residues 1–123 of SEQ ID NO:2 and amino acid residues 141–249 of SEQ ID NO:2 and wherein said B Lymphocyte Stimulator protein is selected from the group consisting of:
Dependencies are inferred from the claim text.