Polypeptides having anti-HIV activity and compositions comprising same
AssigneeBiokine Therapeutics Ltd.
InventorNobutaka Fujii
Life of this patent
Estimating the term…
Abstract
Polypeptides of A1-Arg-A2-Cys-Tyr-A3-A4-X-A5-A6-Cit Cys-A7 (I) or their salts (wherein A1 is hydrogen or a residue of arginine, lysine, ornithine, citrulline, alanine, or the like; A2 is an aromatic amino acid residue; A3, A4 and A6 are each a residue of arginine, lysine, ornithine, citrulline, or alanine; A5 is a residue of tyrosine, phenylalanine, alanine, naphthylalanine, or citrulline; A7 is a lysine or arginine residue whose carboxyl group may be converted into amido; and X is a residue of D-ornithyl-proline, prolyl-D-ornithine, D-lysylproline, or the like, with the proviso that any one of A1, A3, A4, A5, A6 and A7 is a residue of alanine or the like or that X is citrulline or the like).
Claims11
A polypeptide or salt thereof represented by one of the following formulas:
- Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DLys-Pro-Tyr-Arg-Cit-Cys-A7, wherein A7 represents an arginine residue in which a carboxyl group is amidated (SEQ ID NO:
- 11);
- Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DLys-Pro-Tyr-Arg-Cit-Cys-Arg (SEQ ID NO:
- 20);
- Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DCit-Pro-Tyr-Arg-Cit-Cys-A7, wherein A7 represents an arginine residue in which a carboxyl group is amidated (SEQ ID NO:
- 15);
- Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DCit-Pro-Tyr-Arg-Cit-Cys-Arg (SEQ ID NO:
- 22;
- or
- Arg-Arg-Nal-Cys-Tyr-Arg-Lys-DCit-Pro-Tyr-Arg-Cit-Cys-A7, wherein A7 represents an arginine residue in which a carboxyl group is amidated (SEQ ID NO:
- 13).
Dependencies are inferred from the claim text.