Molecular antigen arrays
AssigneeCytos Biotechnology AG
InventorsMartin F. Bachmann, Alain Tissot, Paul Pumpens, Indulis Cielens, Regina Renhofa
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Abstract
The present invention provides a composition comprising an AP205 virus like particle (VLP) and an antigen. The invention also provides a process for producing an antigen or antigenic determinant bound to AP205 VLP. AP205 VLP bound to an antigen is useful in the production of compositions for inducing immune responses that are useful for the prevention or treatment of diseases, disorders or conditions including infectious diseases, allergies, cancer, drug addiction, poisoning and to efficiently induce self-specific immune responses, in particular antibody responses.
Claims16
A nucleic acid molecule comprising the nucleotide sequence as set forth in SEQ ID NO:125.
A virus-like particle comprising at least one protein selected from the group consisting of:
- (a) a protein comprising amino acids 2–131 of SEQ ID NO:1;
- (b) a protein comprising amino acids 2–131 of SEQ ID NO:3;
- and
- (c) a mutein of SEQ ID NO:1, wherein said mutein consists of an addition, deletion or substitution of one to three amino acids from amino acids 1–131 of SEQ ID NO:1.
A vector for producing an AP205 virus-like particle, wherein said vector comprises a nucleotide sequence encoding a protein comprising amino acids 2–131 of SEQ ID NO:3.
A vector for producing an AP205 virus-like particle, wherein said vector comprises a nucleotide sequence encoding a mutein of SEQ ID NO:1, wherein said mutein consists of an addition, deletion or substitution of one to three amino acids from amino acids 2–131 of SEQ ID NO:1.
Dependencies are inferred from the claim text.