Optimized sensor geometry for an implantable glucose sensor

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a sensor body comprising a sensing region adapted for transport of an analyte thereto, and a porous biointerface material that covers at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, and wherein the body comprises a first major surface on which said sensing region is located and a second major surface, wherein the first major surface has edges between which a width of the first major surface can be measured, and wherein the sensing region is spaced away from the edges by a distance that is at least about 10% of the width of the first major surface.

The sensor of 20, wherein the sensing region is spaced away from the edges by a distance that is at least about 15% of the width of the first major surface.

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a sensor body comprising a sensing region adapted for transport of an analyte thereto, and a porous biointerface material that covers at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the sensor comprises a major surface and wherein said curved portion is located on at least a portion of the major surface, and wherein the body comprises a first major surface on which said sensing region is located and a second major surface, wherein the first major surface is at least slightly convex.

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a sensor body comprising a sensing region adapted for transport of an analyte thereto, and a porous biointerface material that covers at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, and wherein the body defines a surface area, and wherein between 10% and 100% of the surface area is convexly curved.

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a sensor body comprising a sensing region adapted for transport of an analyte thereto, and a porous biointerface material that covers at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, and wherein the body defines a surface area, and wherein a substantial portion of the surface area is convexly curved.

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a sensor body comprising a sensing region adapted for transport of an analyte thereto, and a porous biointerface material that covers at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, and wherein the body defines a surface area, and where at least about 90% of the surface area is convexly curved.

An implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:

• a body having a first major surface and, opposite thereto, a second major surface, wherein the first major surface is generally planar, slightly convex, and has rounded edges, with an electrochemical sensing region located on the first major surface that is spaced away from the rounded edges and a porous biointerface material covering at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the first major surface is sufficiently convex that when a foreign body capsule forms around the sensor, contractile forces are exerted thereby generally uniformly towards the sensing region.

An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:

• a body, the body comprising a sensing region adapted for transport of analytes thereto, and a porous blointerface material covering at least a portion of the sensing region, wherein the porous biointerface material covering the portion of the sensing region supports tissue ingrowth, wherein the sensing region is located on a major surface of the body, wherein said major surface comprises a continuous curvature substantially across the entire surface of the body, and wherein a thermoset plastic material substantially encapsulates the body outside the sensing region.