System and methods for optimized drug delivery and progression of diseased and normal cells
AssigneeOptimata Ltd.
InventorsZvia Agur, Sarel Fleishmann, Kirill Skomorovski, Moshe Vardi
Life of this patent
Estimating the term…
Abstract
A system for modeling thrombopoietic lineage in an individual is presented. The system comprises a thrombopoiesis system model including a process progression model, for cells involved in thrombopoiesis, said progression model including multiplication and differentiation. It further comprises a system model modifier, wherein said thrombopoiesis system model is modified by the system model modifier based on parameters specific to the individual. In addition to modifying an individual's thrombopoietic process, the system can be modified to portray different pathological scenarios as well as different scenarios of response to treatment.
Claims50
A system for modeling thrombopoietic lineage in an individual, said system comprising:
- a thrombopoiesis system model including a process progression model, for cells involved in thrombopoiesis, said progression model including multiplication and differentiation;
- and
- a system model modifier, wherein said thrombopoiesis system model is modified by the system model modifier based on parameters specific to the individual.
A system for modeling thrombopoietic lineage in a general patient, said system comprising a thrombopoiesis system model including a process model for cells involved in thrombopoiesis, wherein said process model further includes a plurality of compartments and
- wherein said compartments include:
- a stem cell (SC) compartment that is capable of modeling bone marrow hemopoietic progenitors that have an ability to differentiate into more than one cell line wherein cells in the stem cell compartment proliferate, mature and differentiate into one of megakaryocyte progenitors and new stem cells;
- a colony forming units-megakaryocytes (CFU-Meg) compartment that is capable of modeling megakaryocyte progenitors getting committed as a megakaryocyte line and spending some time multiplying and maturing;
- a megakaryoblast (MKB) compartment that is capable of modeling receiving of cells from CFU-Meg compartment, wherein the cells in the MKB compartment have lost their ability to proliferate but are not mature to release platelets;
- an MK16 compartment that is capable of modeling receiving of cells from the MKB compartment, wherein a subset of cells in the MK16 compartment releases platelets at a constant rate until the subset of cells exhausts its capacity to release platelets and is disintegrated and a second subset of cells does not release platelets but continues with endomitosis;
- an MK32 compartment that is capable of modeling receiving of the second subset of cells from the MK16 compartment, wherein a subset of cells in this compartment releases platelets and a second subset of cells does not release platelets but continues with endomitosis;
- an MK64 compartment that is capable of modeling receiving of the second subset of cells from the MK32 compartment wherein a subset of cells in this compartment releases platelets and a second subset of cells does not release platelets but continues with endomitosis;
- an MK128 compartment that is capable of modeling receiving of the second subset of cells from the MK64 compartment wherein a subset of cells in this compartment releases platelets;
- a platelets (PL) compartment.
A system for modeling thrombopoietic lineage in a general patient, said system comprising a thrombopoiesis system model including a process model for cells involved in thrombopoiesis, wherein said process model further includes a plurality of components wherein each of said compartments is further divided into sub-compartments, each of said sub-compartments containing cells of a specific age in hours
- wherein cells that spend all their corresponding transit time in a given compartment pass on to the next compartment, wherein cells that have left a corresponding compartment each hour fill the first sub-compartment of the next compartment.
A method for modeling thrombopoietic lineage in an individual, said method comprising:
- modeling a process to create a process model for cells involved in thrombopoiesis;
- and
- modifying the process model based on parameters specific to the individual.
Dependencies are inferred from the claim text.