Generation of combinatorial synthetic libraries and screening for proadhesins and nonadhesins
AssigneeCerno Biosciences LLC
InventorsRandall S. Alberte, Robert D. Smith
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Abstract
One aspect of the present invention relates to compounds, comprising at least two moieties selected from the group consisting of aryl sulfonates and aryl sulfates. A second aspect of the present invention relates to combinatorial libraries of the aforementioned compounds. The present invention also relates to compositions comprising a compound of the present invention. A fourth aspect of the present invention relates to the use of a compound or composition of the present invention in a method for inhibiting bioadhesion to a surface. Another aspect of the present invention relates to the use of a compound or composition of the present invention in a method for enhancing bioadhesion to a surface.
Claims18
A compound represented by 1:
- wherein
- X represents independently for each occurrence a bond, O, S, or NR′;
- Z represents independently for each occurrence alkylsulfonyl, fluoroalkylsulfonyl, arylsulfonyl, or S(O)2OH;
- Ar and Ar′ are independently selected from the group consisting of optionally substituted aryl and heteroaryl;
- T represents a covalent tether connecting Ar and Ar′, wherein said covalent tether comprises an amide, ether, substituted amine or ester moiety;
- R′ represents independently for each occurrence H, alkyl, alkenyl, aryl, aralkyl, formyl, acyl, sulfonyl, or —(CH2)m—R80;
- R80 represents independently for each occurrence aryl, cycloalkyl, cycloalkenyl, or heterocyclyl;
- and
- m is an integer in the range 0 to 8 inclusive.
Dependencies are inferred from the claim text.