Aniline derivatives or salts thereof and cytokine production inhibitors containing the same

An aniline derivative of the formula (I′) or a salt thereof, said derivative and salt having cytokine production inhibitor activity:

• wherein A is CO or SO2;
• each of R1 and R2 which are independent of each other, is a halogen atom, a cyano group, a nitro group, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, an amino group which may be substituted or a —B-Q group (wherein B is O, CO, COO, OCO, S, SO or SO2;
• Q is a hydrogen atom, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, a cycloalkyl group which may be substituted, a cycloalkenyl group which may be substituted, an aryl group which may be substituted, or an amino group which may be substituted);
• wherein the substituent of each of the alkyl group which may be substituted, the alkenyl group which may be substituted and the alkynyl group which may be substituted, is a halogen atom, a hydroxyl group, a mercapto group, an alkoxy group, an alkylthio group, an alkenyloxy group, an alkenylthio group, an alkynyloxy group, an alkynylthio group, a cycloalkyl group, a cycloalkenyl group, a cycloalkoxy group, a cycloalkylthio group, a cycloalkenyloxy group, a cycloalkenylthio group, an alkoxycarbonyl group, an alkylcarbonyl group, an alkylcarbonyloxy group, an alkenyloxycarbonyl group, an alkenylcarbonyl group, an alkenylcarbonyloxy group, an alkynyloxycarbonyl group, an alkynylcarbonyl group, an alkynylcarbonyloxy group, a cycloalkoxycarbonyl group, a cycloalkylcarbonyl group, a cycloalkylcarbonyloxy group, a cycloalkenyloxycarbonyl group, a cycloalkenylcarbonyl group, a cycloalkenylcarbonyloxy group, an aryl group, an aryloxy group, an arylthio group, an aryloxycarbonyl group, an arylcarbonyl group, an arylcarbonyloxy group, an amino group, a cyano group, a nitro group, a carboxyl group, an amin ocarbonyl group, an alkylsulfonyl group, an alkenylsulfonyl group, an alkynylsulfonyl group, a cycloalkylsulfonyl group, a cycloalkenylsulfonyl group, an arylsulfonyl group, or an aminosulfonyl group;
• the substituent of each of the cycloalkyl group which may be substituted, the cycloalkenyl group which may be substituted, and the aryl group which may be substituted, is a halogen atom, a hydroxyl group, a mercapto group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an alkenyloxy group, an alkenylthio group, an alkynyloxy group, an alkynylthio group, a cycloalkyl group, a cycloalkenyl group, a cycloalkoxy group, a cycloalkylthio group, a cycloalkenyloxy group, a cycloalkenylthio group, an alkoxycarbonyl group, an alkylcarbonyl group, an alkylcarbonyloxy group, an alkenyloxycarbonyl group, an alkenylcarbonyl group, an alkenylcarbonyloxy group, an alkynyloxycarbonyl group, an alkynylcarbonyl group, an alkynylcarbonyloxy group, a cycloalkoxycarbonyl group, a cycloalkylcarbonyl group, a cycloalkylcarbonyloxy group, a cycloalkenyloxycarbonyl group, a cycloalkenylcarbonyl group, a cycloalkenylcarbonyloxy group, an aryl group, an aryloxy group, an arylthio group, an aryloxycarbonyl group, an arylcarbonyl group, an arylcarbonyloxy group, an amino group, a cyano group, a nitro group, a carboxyl group, an aminocarbonyl group, an alkylsulfonyl group, an alkenylsulfonyl group, an alkynylsulfonyl group, a cycloalkylsulfonyl group, a cycloalkenylsulfonyl group, an arylsulfonyl group, or an aminosulfonyl group;
• the substituent of the amino group which may be substituted is a hydroxyl group, an alkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkenyloxy group, an alkynyloxy group, a cycloalkyl group, a cycloalkenyl group, a cycloalkoxy group, a cycloalkenyloxy group, an alkoxycarbonyl group, an alkylcarbonyl group, an alkenyloxycarbonyl group, an alkenylcarbonyl group, an alkynyloxycarbonyl group, an alkynylcarbonyl group, a cycloalkoxycarbonyl group, a cycloalkylcarbonyl group, a cycloalkenyloxycarbonyl group, a cycloalkenylcarbonyl group, an aryl group, an aryloxy group, an aryloxycarbonyl group, an arylcarbonyl group, an aminocarbonyl group, an alkylsulfonyl group, an alkenylsulfonyl group, an alkynylsulfonyl group, a cycloalkylsulfonyl group, a cycloalkenylsulfonyl group, an arylsulfonyl group, or an aminosulfonyl group;
• R4 is a hydrogen atom or an alkyl group;
• y is an integer of from 0 to 4;
• Hal is a halogen atom;
• Cy′ is a phenyl group M is O, S, a NR6 group (wherein R6 is a hydrogen atom or an alkyl group), —OCH2—, —OCH2CH2—, —CH2O—, —CH2CH2O—, —SCH2—, —SCH2CH2—, —CH2S—, —CH2CH2S—or a single bond;
• R5′ a pyridyl group which may be substituted with at least one substituent selected from the group consisting of a halogen atom, a hydroxyl group, a mercapto group, an alkyl group, a haloalkyl group, an alkenyl group, an alkynyl group, an alkoxy group, an alkylthio group, an alkenyloxy group, an alkenylthio group, an alkynyloxy group, an alkynylthio group, a cycloalkyl group, a cycloalkenyl group, a cycloalkoxy group, a cycloalkylthio group, a cycloalkenyloxy group, a cycloalkenylthio group, an alkoxycarbonyl group, an alkylcarbonyl group, an alkylcarbonyloxy group, an alkenyloxycarbonyl group, an alkenylcarbonyl group, an alkenylcarbonyloxy group, an alkynyloxycarbonyl group, an alkynylcarbonyl group, an alkynylcarbonyloxy group, a cycloalkoxycarbonyl group, a cycloalkylcarbonyl group, a cycloalkylcarbonyloxy group, a cycloalkenyloxycarbonyl group, a cycloalkenylcarbonyl group, a cycloalkenylcarbonyloxy group, an aryl group, an aryloxy group, an arylthio group, an aryloxycarbonyl group, an arylcarbonyl group, an arylcarbonyloxy group, an amino group, a cyano group, a nitro group, a carboxyl group, an aminocarbonyl group, an alkylsulfonyl group, an alkenylsulfonyl group, an alkynylsulfonyl group, a cycloalkylsulfonyl group, a cycloalkenylsulfonyl group, an arylsulfonyl group, and an aminosulfonyl group;
• or R5′ is an adamantyl group;
• x′ is an integer of from 0 to 3.