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US 7,132,535 B2Granted
Process for preparing hexahydropyridazine-3-carboxylic acid derivatives
AssigneeIsochem
InventorsHervé Lhermitte, Charles-Henri Vincent, Christian Picherit
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Abstract
According to the process of the invention, the hexahydropyridazine-3-carboxylic acid derivatives are prepared by reacting a compound of formula (II) with a compound of formula (III) in the presence of a base with a pK of greater than or equal to 8.5, in a ketone organic solvent, to obtain an intermediate compound that is not isolated and that is treated with a basic aqueous medium. By means of this process, the derivatives are obtained more quickly and more economically.
Claims15
A process for preparing a hexahydropyridazine-3-carboxylic acid derivative of the formula
- wherein R is selected from the group consisting of saturated or unsaturated, substituted or unsubstituted alkyl, substituted or unsubstituted aralkyl substituted or unsubstituted aryl comprising reacting a compound of the formula
- wherein R2 is substituted or unsubstituted alkyl and R3 a nucleofugal organic group, with a compound of the formula
- whereas R has the above meaning, in the presence of a base with a pKa greater than or equal to 8.5, in an organic ketone solvent to a tetrahydro- 1,2,3-pyridazine-tricarboxylate intermediate compound of the formula
- wherein R and R2 have the above meanings, which is not isolated and which is treated with a basic aqueous medium, to obtain the hexahydropyridazine-3-carboxylic acid derivative of formula (I).
1 more element
Dependencies are inferred from the claim text.