Back to results
US 7,132,422 B2Granted
Sodium channel modulators
AssigneeTheravance, Inc.
InventorsSeok-Ki Choi, Paul R. Fatheree, David C. Green, Daniel Marquess
Life of this patent
Estimating the term…
Abstract
The invention provides sodium channel modulating compounds which are useful for treating diseases or conditions associated with sodium channel activity, such as neuropathic pain. The invention also provides pharmaceutical compositions comprising a compound of the present invention, as well as therapeutic methods comprising administering such a compound or salt to a mammal (e.g. a human).
Claims11
A compound of formula (VI):
- wherein:
- A12 and A13 are each independently alkylene or substituted alkylene;
- each R29 is independently halo, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR4R5, or CO2R6;
- each R30 is independently halo, alkyl, substituted alkyl, aryl, heteroaryl, cycloalkyl, substituted cycloalkyl, heterocycle, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, trifluoromethyl, cyano, nitro, hydroxy, NR4R5, or CO2R6;
- R31 is hydrogen, alkyl, or substituted alkyl;
- R32 is 2-morpholinoethyl, 2-(pyrrolidin-1-yl)ethyl 4-piperidinylmethyl, 3-(N,N-dimethylamino)propyl, 2-(1-methyl-pyrrolidin-2-yl)ethyl, 2-(4-pyridyl)ethyl, or 3-(pyrrolidin-1-yl)propyl;
- r is 0, 1, 2, 3, 4, or 5;
- q is 0, 1, 2, 3, 4, or 5;
- and
- R4–R6 are each independently hydrogen, alkyl, or substituted alkyl;
- wherein any aryl of A12, A13, R29–R32 and R4–R6 can optionally be substituted with from 1 to 5 substituents Rg;
- wherein each Rg is independently selected from the group consisting of hydroxy, alkyl, substituted alkyl, alkoxy, cycloalkoxy, substituted cycloalkoxy, methanediol, ethanediol, cycloalkyl, substituted alkyl, substituted alkoxy, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxy, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heteroaryl, heteroaryloxy, heterocyclic, heterocyclooxy, heteroaryl and trihalomethyl;
- and wherein any heteroaryl of A12;
- A13, R29–R32 and R4–R6 can be optionally substituted with 1 to 5 substituents Rh, wherein each Rh is independently selected from the group consisting of hydroxy, alkyl, alkoxy, substituted alkoxy, cycloalkoxy, substituted cycloalkoxy, substituted alkyl, arylalkyl, heteroarylalkyl, heterocyclealkyl, substituted cycloalkyl, amino, substituted amino, aryl, aryloxy, carboxyl, carboxylalkyl, carboxyl(substituted alkyl), cyano, halo, nitro, heterocyclic, and trihalomethyl.
- or a pharmaceutically acceptable salt thereof.
12 more elements
Dependencies are inferred from the claim text.