Method for neural stem cell differentiation using 5HT-1A agonists
AssigneePsychiatric Genomics, Inc.
InventorsPrithi Rajan, C. Anthony Altar
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Abstract
The present invention relates to a method for differentiating a neural stem cell into a neuronal cell such as a neuroblast or a neuron in vitro or in vivo. Particularly, the invention provides for a method for neural stem cell differentiation by contacting the neural stem cell with a 5HT1A ligand or agonist.
Claims26
A method for preparing a population of mammalian neural cells enriched with neuronal cells comprising the step of exposing a population of mammalian neural stem cells expanded in culture in the presence of bFGF to a 5HT1A agonist in vitro in the absence of bFGF in an amount and at a frequency of exposure sufficient to induce differentiation of said stem cells to express a neuronal cell marker.
A method for preparing a population of mammalian neural cells enriched with neuronal cells comprising the step of exposing a population of mammalian neural stem cells with buspirone in vitro in an amount and at a frequency of exposure sufficient to induce differentiation of said stem cells to express a neuronal cell marker.
Dependencies are inferred from the claim text.