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US 7,132,049 B2Granted
Negatively charged membrane
AssigneePall Corporation
InventorsChung-Jen Hou, Peter Konstantin, Yujing Yang
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AssigneePall Corporation
InventorsChung-Jen Hou, Peter Konstantin, Yujing Yang
Estimating the term…
The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
A fluid treatment element comprising a plurality of negatively charged microporous membranes, each negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant negatively charged groups, wherein the crosslinked coating is prepared from a polymerized composition comprising an unsaturated monomer having a negatively charged group, at least one N-(hydroxyalkyl)- or N-(alkoxyalkyl)- acrylamide, and a hydrophilic unsaturated monomer.
A fluid treatment device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, a plurality of negatively charged microporous membranes, each negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant negatively charged groups, wherein the crosslinked coating is prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, at least one N-(hydroxyalkyl)- or N-(alkoxyalkyl)-acrylamide, and a hydrophilic unsaturated monomer.
A fluid treatment element comprising a plurality of negatively charged microporous membranes, each negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant negatively charged groups, wherein the crosslinked coating comprises amide-ester and amide-amide crosslinks.
A fluid treatment device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, a plurality of negatively charged microporous membranes, each negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant negatively charged groups, wherein the crosslinked coating comprises amide-ester and amide-amide crosslinks.
Dependencies are inferred from the claim text.