US 7,129,377 B2Granted

Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer

AssigneeUniversity of Tennessee Research Foundation

InventorsDuane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee

Life of this patent

Estimating the term…

Abstract

The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor.

Claims2

Dependent claims

A compound having the structure of the formula:

where R1 and R3 are a hydrogen;
R2 is a nitro;
R4 is a hydrogen;
R5 is a hydroxyl;
R6 is an alkyl;
A1 and A2 is the same or different, each is a direct link or an alkylene;
X1 is an oxygen;
and
R7 is a phenyl substituted with an alkylamido group or a haloalkylamido group.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 10/884,403Filed 6 Jul 2004 · continuation
Priority: 27 Nov 1996
Published: US 2004/0248862 A19 Dec 2004
Granted: 31 Oct 2006
Term ends: Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07C 331/08
Thiocyanates: having sulfur atoms of thiocyanate groups bound to carbon atoms of six-membered aromatic rings
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
C07C 317/46
Having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton: the carbon skeleton being further substituted by…
C07C 323/60
Having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton: with the carbon atom of at least one of the…

Family

Application60/031,861Us provisional application · filed 27 Nov 1996
Application08/978,511Parent of this continuation · filed 25 Nov 1997
Application09/510,108Parent of this continuation · filed 22 Feb 2000
Application10/298,229Parent of this continuation · filed 18 Nov 2002
US 2004/0248862 A1Pre-grant publication · published 9 Dec 2004
US 7,041,844 B2Parent of this continuation
US 6,482,861 B2Parent of this continuation
US 6,071,957 AParent of this continuation
US 2001/0012839 A1Published application
US 2003/0232882 A1Published application
US 7,129,377 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

patentgrep

Loading patent…

Abstract

Facts

Application

10/884,403Filed 6 Jul 2004 · continuation

Priority

27 Nov 1996

Published

US 2004/0248862 A19 Dec 2004

Granted

31 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

C07C 331/08
Thiocyanates: having sulfur atoms of thiocyanate groups bound to carbon atoms of six-membered aromatic rings
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
C07C 317/46
Having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton: the carbon skeleton being further substituted by…
C07C 323/60
Having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton: with the carbon atom of at least one of the…

Family

Application60/031,861Us provisional application · filed 27 Nov 1996

Application08/978,511Parent of this continuation · filed 25 Nov 1997

Application09/510,108Parent of this continuation · filed 22 Feb 2000

Application10/298,229Parent of this continuation · filed 18 Nov 2002

US 2004/0248862 A1Pre-grant publication · published 9 Dec 2004

US 7,041,844 B2Parent of this continuation

US 6,482,861 B2Parent of this continuation

US 6,071,957 AParent of this continuation

US 2001/0012839 A1Published application

US 2003/0232882 A1Published application

US 7,129,377 B2This patent

From the US filing history. Foreign family members aren’t listed.