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US 7,129,366 B2Granted
Group of a novel anti-cancer compounds with specific structure
AssigneeYang's Biochem Co. Ltd.
InventorZhenhua Yang
Life of this patent
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Abstract
Compounds containing a specific saturated or unsaturated branched chain terminal group; a polar leading group; and a long-chain aliphatic, non-cyclic, saturated or unsaturated, substituted or unsubstituted, hydrocarbon group linking them; and having anti-cancer, immunosuppression alleviation, immune boosting and anti-inflammation activity.
Claims12
A compound having a formula selected from the group consisting of the following formulae (6) and (8) through (12):
- wherein n is an integer from 5 to 19, m is an integer from 0 to 2b+x, inclusive, wherein b is the maximum number of unsaturated bonds, and wherein a double bond is assigned as 1 and a triple bond is assigned as 2, and R1, R2, and R3, are chemically possible groups to form the structures above, provided that R2R3 is a polar moiety, x is the number of R1 groups (same or different) at any possible position (x is an integer≦2n−m), and the salt thereof, and provided that when the compound has formula (6), m is 0, and (R1)x are all hydrogen when x is not 0, then R2R3 is not carboxyl.
A compound selected from the group consisting of:
- 11-Methyl-dodeca-2,4-dienoic acid,
- 13-Methyl-9-tetradecene acid,
- 12-Ethyl-12-tridecenoic acid,
- 9-Ethyl-11-methyl-dodecanoic acid,
- 9-Hydroxy-11-methyl-dodecanoic acid,
- 2-Amino-11-methyl-dodecanoic acid,
- 9-Mercapto-11-methyl-dodecanoic acid,
- 9-Oxo-11-methyl-dodecanoic acid,
- 9-Hydroxyimino-11-methyl-dodecanoic acid,
- 3-Chloro-11-methyl-dodecanoic acid,
- 9-Carboxymethylamino-11-methyl-dodecanoic acid,
- 2-Glucosamino-11-methyl-dodecanoic acid,
- 4-(8-Methyl-nonyl)-5-carboxy-tetrahydroimidazoyl-2-one,
- 7-(6N-Adenyl)-9-methyl-decanoic acid,
- 11-Methyl-9-oxo-dodecyl(3,4,5-trihydroxy)benzoate,
- 13-Methyl-3-oxo-tetradecanal,
- Sodium 1-hydroxy 3-oxo-15-methyl-hexadecyl-sulfonate,
- N-(-13-Methyl-tetradecanoyl)-2-amino-7-ribo purine,
- 2N-(13-Methyl-tetradecanoyl)-guanosine,
- 2N-(13-Methyl-tetradecanoyl)guanine,
- 6N-(11-Methyl-dodecanoyl)adenine,
- N,N-Diethyl-10-methylundecylamine,
- N,N-di(2-aminoethyl)-12-methyl-tridecylamine tri-hydrochloride,
- 13-Methyl-tetradecanal-N-hydroxyimine,
- N-4-Carboxy-benzyl-(11-methyl-3-oxo-dodecyl)imine,
- 2-(10-Methyl-undecyl)-adenine hydrochloride,
- 2-(9-Methyl-decyl)-adenine,
- 2-(11-Methyldodecyl)-4-amino-pyrimidine hydrochloride,
- Sodium 2-(5-hydroxy-1-imidazolyl)-11-methyl-dodecanoate,
- 12-methyl-1,10-tridecanediol,
- 6-[(N-11-Methyl-dodecanoyl)glycyl]thymine,
- 13-Methyl-tetradecyl urea,
- (1-Methyl-9-hydroxy-dodecyl)ethyl ether,
- 12-Methyl-3-oxo-tridecyl-3,4,5-trihydroxy benzoate,
- 1-(2-Chloroethyl)-1-nitroso-3-(12-methyl-tridecyl)urea,
- N-4-Methyl-benzenesulfonyl-13-Methyl-tetradecyl amine,
- (5-Carboxy-2,3,-dihydroxy phenyl)13-methyl-tetradecanoate,
- 6N-13-methyl-tetradecyl-5-flucytosine,
- 6N-(13-Methyl-tetradecanoyl)adenosine,
- 1N-(13-methyl-tetradecanoyl)-5-fluoropyrimidine-2,4-dione,
- N,N-Di(2-chloroethyl)-4-(13-methyl-tetradecyl)aniline,
- 2-(2,4-Dihydroxyphenyl)-13-methyl tetradecanoic acid,
- N-(12-methyl-tridecyl)hydrazine hydrochloride,
- 10-Methoxy-12-methyl-tridecanol,
- (12-Methyl-tridecyl)-2,4-dimethoxy benzene,
- 12-Methyl-3-oxo-tridecyl-3,4,5-trimethoxy-benzoate, and
- (5-Carboxy-2,3-dimethoxy phenyl)13-methyl-tetradecanoate.
44 more elements
A method of treating inflammation comprising applying a compound having a formula selected from the group consisting of the following formulae (4) through (12):
- wherein n is an integer from 5 to 19, m is an integer from 0 to 2b+x, inclusive, wherein b is the maximum number of unsaturated bonds, and wherein a double bond is assigned as 1 and a triple bond is assigned as 2, and R1, R2, and R3, are chemically possible groups to form the structures above, provided that R2R3 is a polar moiety, x is the number of R1 groups (same or different) at any possible position (x is an integer≦2n−m), and the salt thereof.
A compound having a formula (7):
- wherein n is an integer from 5 to 19, m is an integer from 0 to 2b+x, inclusive, wherein b is the maximum number of unsaturated bonds, and wherein a double bond is assigned as 1 and a triple bond is assigned as 2, and R1, R2, and R3, are chemically possible groups to form the structures above, provided that R2R3 is a polar moiety, x is the number of R1 groups (same or different) at any possible position (x is an integer≦2n+m), and the salt thereof, provided that when R2R3contains a heterocyclic group, it is a nitrogen-containing heterocyclic group.
Dependencies are inferred from the claim text.