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US 7,129,330 B1Granted
Multivalent antibody constructs
AssigneeDeutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts
InventorsMelvyn Little, Sergej Kipriyanov
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Abstract
The present invention relates to multivalent Fvantibody construct having at least four variable domains which are linked with each over via the peptide linkers 1, 2 and 3. The invention also concerns expression plasmids which code for such an Fvantibody construct and a method of producing the Fvantibody constructs as well as their use.
Claims4
A bispecific tetravalent homodimeric Fv antibody formed by two single-chain Fv monomers, each of said Fv monomers having at least four variable domains, wherein
- said four variable domains are VH-A, VL-A, VH-B and VL-B, wherein VH-A and VL-A are VH and VL domains of an antibody specific for antigen A, respectively, and VH-B and VL-B are VH and VL domains of an antibody specific for antigen B, respectively;
- VH-A is linked to VL-B by peptide linker 1, VL-B is linked to VH-B by peptide linker 2, VH-B is linked to VL-A by peptide linker 3;
- and
- said peptide linker 1 and said peptide linker 3 are a peptide bond or have about 1 to about 10 amino acids;
- and said peptide linker 2 has 3 to about 10 amino acids.
2 more elements
Dependencies are inferred from the claim text.