Hydrophobic multicomponent heparin conjugates, a preparing method and a use thereof
AssigneeMediplex Corporation, Korea
InventorsYoung Ro Byun, Hyun Tae Moon
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Abstract
The present invention provides hydrophobic heparin conjugates that are soluble in organic solvents but not in water, a method of preparing them, and a method of using them. Particularly, the present invention provides hydrophobic heparin conjugates that are prepared by covalently binding a polymer to heparin and a hydrophobic agent to the polymer. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogenic effect and are insoluble in water due to their hydrophobicity, so they can be effectively used as coating agents for modifying the surfaces of medical devices.
Claims12
A hydrophobic heparin conjugate wherein heparin is covalently bonded to multiple macromolecules containing multiple functional groups therein, and wherein multiple hydrophobic materials selected from the group consisting of octadecylamine (ODA), alkanoic amines, bile acids, sterols, and alkanoic acids are covalently bonded to each macromolecule through the functional groups.
Dependencies are inferred from the claim text.