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US 7,129,091 B2Granted
Device and method for pressure-driven plug transport and reaction
AssigneeThe University of Chicago
InventorsRustem F. Ismagilov, Joshua David Tice, Helen Song
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Abstract
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
Claims32
A method of conducting a reaction within at least one plug comprising the steps of:
- introducing a carrier-fluid into a first microchannel of a device;
- simultaneously introducing at least two streams of plug-fluids into a first inlet in fluid communication with the first microchannel so that at least one plug forms in the carrier-fluid after the streams contact the carrier-fluid;
- wherein:
- a first plug-fluid comprises a first reagent;
- a second plug-fluid comprises a second reagent;
- each plug-fluid is immiscible with the carrier-fluid;
- and
- each plug comprises both the first and second plug-fluids so that the reaction of the reagents substantially occurs in the plug;
- each plug is substantially surrounded by carrier.
6 more elements
Dependencies are inferred from the claim text.