Porous silica microsphere scavengers
AssigneeAgilent Technologies, Inc.
InventorsJoseph J. Kirkland, Timothy J. Langlois, Qunjie Wang
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Abstract
Highly purified, porous silica microspheres contain functional groups which are capable of selectively binding to reaction impurities, such as excess reactant or reaction by-products, which are contained in a reaction medium. The reaction impurities can thereby be efficiently removed from the reaction medium, providing a convenient method for product purification.
Claims25
Highly purified porous silica microspheres, having nominal diameters in the range of from about 10 microns to about 200 microns, and a porosity of at least about 50%, said microspheres are hydroxylated to create surface silanol groups and reacted with silane containing functional groups, said microspheres having a pH of about 6 to about 7, wherein said functional groups are capable of binding with an impurity in a reaction medium containing the impurity and a reaction product, and selectively remove the impurity.
A method of removing impurities from a reaction mixture containing a product and impurities comprising:
- contacting said reaction mixture with porous silica microspheres, said microspheres having a nominal diameter range of from about 10 microns to about 200 microns, a porosity of at least about 50%, said microspheres having a pH of about 6 to about 7, wherein said microspheres are hydroxylated to create surface silanol groups and reacted with silane containing functional groups, wherein said functional groups are capable of binding with said impurities, thereby selectively removing said impurities from said reaction mixture.
Highly purified, porous silica microspheres, having nominal diameters in the range of from about 10 microns to about 200 microns, and a porosity of at least about 50%, said microspheres containing functional groups which are capable of binding with an impurity in a reaction medium containing the impurity and a reaction product, and selectively removing the impurity.
Dependencies are inferred from the claim text.