Mouse model for aging
AssigneeWisconsin Alumni Research Foundation
InventorsTomas A. Prolla, Gregory C. Kujoth
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Abstract
A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamma (PolG) gene, wherein the mutation leads to high levels of mutations in polymerase mtDNA.
Claims9
A transgenic mouse model for mouse aging comprising a mouse having a targeted site-directed mutation in the exonuclease domain II of the endogenous mitochondrial DNA polymerase gamma gene, wherein said targeted site-directed mutation is the substitution of an aspartic acid residue to an alanine residue at position 257 as set forth in SEQ ID NO:3, wherein said mutation results in an elevated mitochondrial mutation frequency in at least two tissues in said mouse model.
Dependencies are inferred from the claim text.