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US 7,126,003 B2Granted
Method for producing 2-azetidinone derivative
AssigneeDaiichi Pharmaceutical Co., Ltd.
InventorsKouji Sato, Tsutomu Yagi, Yutaka Kitagawa, Shigeru Ichikawa, Akihiro Imura
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Abstract
A process for producing a compound represented by the following formula (II) which comprises treating a compound represented by the following formula (I) (wherein R1, R2 and R3 represent each a specific substituent) with an enzyme capable of asymmetrically hydrolyzing an ester and the novel compound (II). The process of the present invention makes it possible to easily obtain an optically active 2-azetidinone derivative in a large amount at a low cost
Claims12
A process for producing a compound represented by formula (II):
- wherein R1 represents a 3-fluoro-2-pyridyl group;
- R2 represents a hydrogen atom, a hydroxyl group, an alkoxyl group having 1 to 6 carbon atoms which may have substituent(s), an alkanoyl group having 1 to 6 carbon atoms which may have substituent(s), an alkenoyl group having 2 to 6 carbon atoms which may have substituent(s), an aryl group which may have substituent(s), an aryloyl group which may have substituent(s) or an aralkyl group which may have substituent(s);
- and R3 represents an alkyl group having 1 to 6 carbon atoms which may have substituent(s) or an alkenyl group having 2 to 6 carbon atoms which may have substituent(s);
- which comprises treating a compound represented by
- formula (I) with an enzyme capable of asymmetrically hydrolyzing an ester:
- wherein R1, R2 and R3 are each as defined above.
3 more elements
A compound represented by formula (II):
- wherein R1 represents a 3-fluoro-2-pyridyl group;
- R2 represents a hydrogen atom, a hydroxyl group, an alkoxyl group having 1 to 6 carbon atoms which may have substituent(s), an alkanoyl group having 1 to 6 carbon atoms which may have substituent(s), an alkenoyl group having 2 to 6 carbon atoms which may have substituent(s), an aryl group which may have substituent(s), an aryloyl group which may have substituent(s) or an aralkyl group which may have substituent(s);
- and R3 represents an alkyl group having 1 to 6 carbon atoms which may have substituent(s) or an alkenyl group having 2 to 6 carbon atoms which may have substituent(s).
Dependencies are inferred from the claim text.