US 7,126,001 B2 · Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Abstract

The present invention provides the compound having the formula: wherein each of R1 and R2 is, substituted or unsubstituted, aryl, cycloalkyl, cycloalkylamino, naphtha, pyridineamino, piperidino, t-butyl, aryloxy, arylalkyloxy, or pyridine group; wherein A is an amido moiety, —O—, —S—, —NH—, or —CH2—; and wherein n is an integer from 3 to 8. The present invention also provides a method of selectively inducing growth arrest, terminal differentiation and/or apoptosis of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically acceptable amount of the compound above.

Claims11

Dependent claims

A compound having the formula:

wherein R1 and R2 are the same or different and are each attached through a linker, and are substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, cycloalkylamino, naphthyl, pyridineamino, piperidino, 9-purine-6-amino, thiazoleamino, hydroxyl, branched or unbranched alkyl, alkenyl, alkyloxy, aryloxy, arylalkyloxy, or pyridinyl group;
wherein R5′ is —C(O)—NHOH(hydroxamic acid);
wherein the linker is an amide moiety, —O—, —S—, —NH—, or —CH2—;
and
n is an integer from 3 to 10,
or an enantiomer or a pharmaceutically acceptable salt thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

10/281,875Filed 25 Oct 2002 · continuation

Priority

8 Sep 1999

Published

US 2004/0002506 A11 Jan 2004

Granted

24 Oct 2006

Term ends

Not estimatedThe source records don’t support an estimate.

Classification32 codes

C07D 213/75
Nitrogen atoms: amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
A61P 35/00
Antineoplastic agents
A61P 43/00
Drugs for specific purposes, not provided for in groups a61p1/00-a61p41/00
C07C 233/07
With carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton: having the nitrogen atom of at…

Family

Application60/152,755Us provisional application · filed 8 Sep 1999

Application60/208,688Us provisional application · filed 1 Jun 2000

Application09/645,430Parent of this continuation · filed 24 Aug 2000

US 2004/0002506 A1Pre-grant publication · published 1 Jan 2004

US 6,511,990 B1Parent of this continuation

US 7,126,001 B2This patent

From the US filing history. Foreign family members aren’t listed.

Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Life of this patent

Class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof

Life of this patent

Abstract

Claims11