Imidazolyl derivatives as corticotropin releasing factor inhibitors

A compound of Formula (I)

• or a pharmaceutically acceptable salt or solvate thereof
• wherein
• R1 is H, C1-6alkyl, C1-6haloalkyl, C1-6alkoxy, C1-6thioalkyl, cyano, halo, C3-7cycloalkyl, —C1-6alkylene-C3-7cycloalkyl, C2-6alkenyl or C3-6alkynyl;
• R2 is C(D)NR3R4, D′-D″(R3)(R4) or CH2NR3R4
• D′ is CH2 or a bond;
• D″ is C, C—OH or CH
• wherein
• said C is attached to R3 by a single or double bond;
• said C is attached to R4 by a single or double bond;
• provided that
• C is not attached to both R3 and R4 by double bonds;
• said CH is attached to R3 and R4 by single bonds;
• said C of C—OH is attached to R3 and R4 by single bonds;
• D is O or S;
• R3 and R4 are each independently selected from the group consisting of H, C1-6alkyl, C1-6haloalkyl, —C1-6hydroxyalkyl, —C1-4alkylene-O—C1-4alkyl, —C1-3alkylene-C1-6thioalkyl, —C2-6alkylidene-(C1-4alkoxy)2, C3-7cycloalkyl, —C1-6alkylene-C3-7cycloalkyl, C2-6alkenyl, C3-6alkynyl, —C1-6alkylene-CN, —C1-6alkylene-heterocyclo and —C1-6alkylene-aryl;
• wherein said aryl of said —C1-6alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro, C1-4alkyl and C1-3alkoxy;
• or
• R3 and R4 together with the nitrogen to which they are attached form a five or six-membered heterocycle,
• said heterocycle optionally containing one additional heteroatom selected from the group consisting of N, S and O;
• and
• said heterocycle optionally substituted with one or more groups selected from the group consisting of C1-6alkyl, C1-6alkoxy, aryl, —C1-4alkylene-aryl, pyridyl and halogen;
• wherein said aryl of said —C1-4alkylene-aryl is optionally substituted with one to three of the same or different substituents selected from the group consisting of fluoro, chloro, bromo, cyano, nitro and C1-3alkoxy;
• X is C;
• Y is C;
• A is
• wherein
• X1 is N and is attached to X;
• Y1 is N and is attached to Y;
• G is
• wherein
• Y2 is CE1 and is attached to Y1;
• J is a bond;
• Z1 is CE3 and is attached to Z;
• wherein
• E1 and E3 together form N—CH═CH—CH═, optionally substituted with halogen, —CN, C1–C4alkyl, C3–C6cycloalkyl, substituted or unsubstituted phenyl, hydroxy, C1–C4alkoxy, SH, C1–C4thioalkyl, NH2, NH(C1–C4alkyl) or N(C1–C4alkyl)2;
• Z is N—V, wherein V is phenyl, 2-pyridyl or 3-pyridyl substituted with two to three of the same or different substituents selected from the group consisting of C1-4alkyl, C1-4alkoxy, C1-6thioalkyl, C1-4haloalkyl, halogen, N(C1–C4alkyl)2 and CN.