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US 7,125,979 B2Granted
Upstream control elements of the proopiomelanocortin gene and their use
AssigneeOregon Health & Science University
InventorsMalcolm J. Low, Marcelo Rubinstein, Flavio Silva Junqueira de Souza
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Abstract
The nucleic acid sequence of the POMC enhancer is disclosed herein. Sequences from the human, rat, rabbit, hamster, mouse, and cow POMC enhancer are disclosed. Hybrid transgenes, comprising a POMC transcriptional control element operably linked to a nucleic acid sequence encoding a marker are also enclosed. In addition, transgenic mice carrying a hybrid transgene including a POMC control element operably linked to a marker are disclosed herein.
Claims25
An isolated proopiomelanocortin enhancer element, comprising a nucleic acid sequence set forth as SEQ ID NO:
- 15, wherein the isolated proopiomelanocortin enhancer element elevates transcription of a heterologous coding sequence in a host cell.
Dependencies are inferred from the claim text.