Derivatized oligonucleotides having improved uptake and other properties

A compound comprising a plurality of linked nucleosides, wherein:

• at least one of the nucleosides is a 2′-deoxy′-2′-fluoro, 2′-O—C1–C20-alkyl, 2′-O—C2–C20-alkenyl, 2′-O—C2–C20-alkynyl, 2′-S—C1–C20-alkyl, 2′-S—C2–C20-alkenyl, 2′-S—C2–C20-alkynyl, 2′-NH—C1–C20-alkyl, 2′-NH—C2–C20-alkenyl, or 2′-NH—C2–C20-alkynyl nucleoside;
• and
• at least one of the nucleosides is a 5′-O-terminal nucleoside having a non-aromatic molecule linked to the 5′-O-position of the nucleoside, provided that the compound does not include sulfamate or sulfamide internucleotide linkages.

A compound comprising a plurality of linked nucleosides, wherein:

• at least one of the nucleosides is a 2′-deoxy′-2′-fluoro, 2′-O—C1–C20-alkyl, 2′-O—C2–C20-alkenyl, 2′-O—C2–C20-alkynyl, 2′-S—C1–C20-alkyl, 2′-S—C2–C20-alkenyl, 2′-S—C2–C20-alkynyl, 2′-NH—C1–C20-alkyl, 2′-NH—C2–C20-alkenyl, or 2′-NH—C2–C20-alkynyl nucleoside;
• and
• at least one of the nucleosides is a 5′-O-terminal nucleoside having a lipophilic molecule linked to the 5′-position of the nucleoside, provided that the compound does not include sulfamate or sulfamide internucleotide linkages.