PRO4405 polypeptides
AssigneeGenentech, Inc.
InventorsLuc Desnoyers, Audrey Goddard, Paul J. Godowski, Austin L. Gurney, William I. Wood
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Abstract
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims11
An isolated polypeptide having at least 95% amino acid sequence identity to:
- (a) the amino acid sequence of the polypeptide of SEQ ID NO:45;
- (b) the amino acid sequence of the polypeptide of SEQ ID NO:45, lacking its associated signal peptide;
- or
- (c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203966, and
- wherein said isolated polypeptide has the ability to induce chondrocyte redifferentiation.
An isolated polypeptide comprising:
- (a) the amino acid sequence of the polypeptide of SEQ ID NO:45;
- (b) the amino acid sequence of the polypeptide of SEQ ID NO:45, lacking its associated signal peptide;
- or
- (c) the amino acid sequence of the polypeptide encoded by the full-length coding sequence of the cDNA deposited under ATCC accession number 203966.
Dependencies are inferred from the claim text.