Malaria polypeptides
AssigneeKarolinska Innovations AB
InventorsMats Wahlgren, Antonio Barragan, Johan Carlson, Chen Qijun, Victor Fernandez
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Abstract
The present invention relates to carbohydrates capable of acting as receptors for malaria antigens present on the surfaces of malaria infected erythrocytes. The receptors according to the invention comprises negatively charged glycosaminoglycan-like moities, preferably sulphated. The invention also relates to novel malaria polypeptides capable of acting as ligands in relation to the receptors according to the invention. The invention also encompasses the use thereof as medicaments, pharmaceutical compositions containing the same as well as antibodies directed against said new ligands.
Claims6
An isolated polypeptide comprising SEQ ID NO:
- 1.
An isolated polypeptide consisting of SEQ ID NO:
- 1.
An isolated polypeptide comprising amino acids 79–415 of SEQ ID NO:
- 1, and wherein SEQ ID NO:1 is a plasmodium erythrocyte membrane protein (PfEMP1) polypeptide.
An isolated polypeptide consisting of amino acids 79–415 of SEQ ID NO:
- 1, and wherein SEQ ID NO:1 is a plasmodium erythrocyte membrane protein (PfEMP1) polypeptide.
Dependencies are inferred from the claim text.