Compounds which prevent neuronal cell death and uses thereof
AssigneeThe Trustees of Columbia University in the City of New York
InventorCarol M. Troy
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Abstract
The present invention provides for a compound having the structure: (AA1)n-Cys-(AA2)m wherein n=0,1,2,3,4 or 5 and m=0,1,2,3,4 or 5, provided the sum of (n+m) is greater than or equal to two and less than or equal to five, if n=1, (AA1)n=Ala-, if n=2, (AA1)n=Gln-Ala-, if n≧3, (AA1)n=(Xaa)p-Gln-Ala-, and Xaa=any amino acid and wherein if n=n3, p=1, if n=4, p=2, if n=5, p=3, if m=1, (AA2)m=-Arg, if m=2, (AA2)m=-Arg-Gly, if m≧3, (AA2)m=-Arg-Gly-(Xaa)q, wherein if m=3, q=1, if m=4, q=2, if m=5, q=3. The present invention provides for a method of inhibiting cell death and a method for alleviating symptoms of a neurodegenerative disorder in a subject.
Claims7
A compound having the structure:
- wherein n=0,1,2,3,4 or 5 and m=0,1,2,3,4 or 5, provided the sum of (n+m) is greater than or equal to two and less than or equal to five,
- if n=1, (AA1)n=Ala-,
- if n=2, (AA1)n=Gln-Ala-,
- if n≧3, (AA1)n=(Xaa)p-Gln-Ala-,
- and Xaa=any amino acid and
- wherein if n=3, p=1,
- if n=4, p=2,
- if n=5, p=3,
- if m=1, (AA2)m=-Arg,
- if m=2, (AA2)m=-Arg-Gly,
- if m≧3, (AA2)m=-Arg-Gly-(Xaa)q,
- wherein if m=3, q=1,
- if m=4, q=2,
- if m=5, q=3,
- wherein each V, V′ or V″ is independently an agent capable of specifically directing the compound to a cell.
Dependencies are inferred from the claim text.