Treating pain using selective antagonists of persistent sodium current
AssigneeAllergan, Inc.
InventorsGeorge R. Ehring, Joseph S. Adorante, John E. Donello, Larry A. Wheeler, Thomas Malone
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Abstract
The present invention provides methods of treating chronic pain in a mammal by administering to the mammal an effective amount of a selective persistent sodium channel antagonist that has at least 20-fold selectivity for persistent sodium current relative to transient sodium current.
Claims51
A method of treating neuropathic pain in a mammal, comprising administering to said mammal an effective amount of a selective persistent sodium channel antagonist, wherein said antagonist has at least 20-fold selectivity for a persistent sodium current relative to a transient sodium current, and wherein said antagonist is a compound included in formula 1, or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof:
- wherein,
- Ar1 is thienyl or a substituted thienyl;
- Ar2 is phenyl or a substituted phenyl;
- Y is absentor
- R1 is selected from the group consisting of hydrogen and a C1 to C8 alkyl;
- R2 and R3 are independently selected from the group consisting of hydrogen, hydroxy, fluoro, and a C1 to C8 alkyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
Dependencies are inferred from the claim text.