Indole derivatives having anti-angiogenetic activity

A compound of Formula (VIId),

• wherein
• R1 is independently selected from hydroxy, amino, alkanoylamino, —OPO3H2, or C1-4alkoxy, wherein the amino group is optionally substituted with an amino acid residue and the hydroxy group is optionally esterified;
• X is selected from —O—, —S—, —SO—, or —SO2—;
• R2 is selected from hydrogen, C1-4alkyl, C1-4alkoxy;
• R4 is independently selected from hydrogen, C1-4alkyl, 1-4alkanoyl, C1-4alkoxycarbonyl, C1-4alkoxycarbonylC1-4alkyl, aminoC1-4alkyl, carbamoyl, carbamoylC1-4alkyl, cyano, cyanoC1-4alkyl, hydroxy or hydroxyC1-4alkyl;
• R5 is selected from hydrogen, C1-4alkyl, or a group of Formula (III)
• wherein
• Y is selected from —NH—, —O—, or a bond;
• Z is selected from —NH—, —O—, —C(O)— or a bond;
• r is an integer from 0 to 4;
• t is an integer from 0 to 1;
• R8 is hydrogen, C1-4alkyl, C1-4alkoxy, aryl, 5- or 6-membered heterocyclyl, 5- or 6-membered heteroaryl, wherein aryl, heteroaryl or heterocyclyl are optionally substituted with C1-4alkyl, C1-4alkoxy, or a group of Formula (IV)
• wherein
• n is an integer from 1 to 6, and;
• R9 and R10 are independently selected from hydrogen, C1-4alkyl or aryl;
• p is an integer from 0 to 1 and
• q is an integer from 1 to 3;
• or a salt, or solvate thereof.