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US 7,125,900 B2Granted
Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
AssigneeBiovitrum AB
InventorsTjeerd Barf, Marianne Nilsson, Jerk Vallgårda, Guido Kurz
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Abstract
The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
Claims2
A compound selected from the group consisting of:
- 3-chloro-2-methyl-N-(4-methyl-1,3-thiazol-2-yl)benzenesulfonamide,
- 3-chloro-2-methyl-N-[4-methyl-5-(2,2,2-trichloroethyl)-1,3-thiazol-2-yl]benzenesulfonamide,
- N-[4-methyl-5-(2,2,2-trichloroethyl)-1,3-thiazol-2-yl]-2,4,6-trichlorobenzenesulfonamide,
- 3-chloro-N-(5-ethyl-4-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,
- 3-chloro-2-methyl-N-(4-methyl-5-propyl-1,3-thiazol-2-yl)benzenesulfonamide,
- 3-chloro-N-(4-ethyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,
- 3-chloro-N-(4-ethyl-5-methyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,
- 3-chloro-2-methyl-N-(4-propyl-1,3-thiazol-2-yl)benzenesulfonamide,
- 3-chloro-N-(4-isopropyl-1,3-thiazol-2-yl)-2-methylbenzenesulfonamide,
- N-(4-butyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide,
- N-(5-butyl-4-methyl-1,3-thiazol-2-yl)-2,4-dichloro-6-methylbenzenesulfonamide,
- N-(4-tert-butyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide,
- ethyl 3-(2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]aminol}-1,3-thiazol-4-yl)-3-methylbutanoate,
- 2,4-dichloro-6-methyl-N-(4-pentyl-1,3-thiazol-2-yl)benzenesulfonamide,
- 3-chloro-2-methyl-N-(4-vinyl-1,3-thiazol-2-yl)benzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-chlorobenzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl) [1,1′-biphenyl]-4-sulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-(3-chloro-2-cyanophenoxy)benzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-propylbenzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,6-trichlorobenzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4-dichloro-6-methylbenzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,4,5-trichlorobenzenesulfonamide,
- X-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-4-bromo-2,5-difluoro-2-benzenesulfonamide,
- N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2,6-dichlorobenzenesulfonamide,
- N-(5-carbethoxy-4-methyl-1,3-thiazol-2-yl)-3-chloro-2-methylbenzenesulfonamide,
- N-(5-carbethoxy-4-methyl-1,3-thiazol-2-yl) [1,1′-biphenyl]-4-sulfonamide,
- N-(5-carbethoxy-4-methyl-1,3-thiazol-2-yl)-4-propylbenzenesulfonamide,
- N-(5-carbethoxy-4-methyl-1,3-thiazol-2-yl)-2,4-dichloro-6-methylbenzenesulfonamide,
- N-(5-carbethoxy-4-methyl-1,3-thiazol-2-yl)-2,4,6-trichlorobenzenesulfonamide.
27 more elements
Dependencies are inferred from the claim text.