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US 7,125,889 B2Granted
Treating of cardiovascular and related pathologies
AssigneeMedicure International Inc.
InventorsRajat Sethi, Wasimul Haque
Life of this patent
Estimating the term…
Abstract
Methods for treating cardiovascular and related diseases such as blood clots are described. The methods are directed to concurrently administering a compound such as pyridoxal-5′-phosphate, pyridoxamine, pyridoxal, or a 3-acylated pyridoxal analogue with a therapeutic cardiovascular compound.
Claims6
A method of reducing blood clots in a mammal comprising:
- concurrently administering to the mammal a therapeutically effective amount for reducing blood clots of a combination of a compound selected from the group consisting of pyridoxal-5′-phosphate, pyridoxal, pyridoxamine, a 3-acylated pyridoxal analogue, a pharmaceutically acceptable acid addition salt thereof, and a mixture thereof, and a cardiovascular compound selected from the group consisting of pyridoxal phophate-6-azophenyl-2′,4′-disulphonic acid (PPADS) and an anti-thrombotic agent, wherein the 3-acylated pyridoxal analogue is a compound of the formula
- wherein
- R1 is a straight or branched alkyl group, a straight or branched alkenyl group, in which an alkyl or alkenyl group may be interrupted by a nitrogen or oxygen atom;
- an alkoxy group;
- a dialkylamino group;
- or an unsubstituted or substituted aryl group;
- and
- R2 is a secondary amino group.
5 more elements
Dependencies are inferred from the claim text.