Substituted heterocyclic compounds

A compound of the formula:

• wherein:
• R1 is chosen from the group consisting of indolyl, indazolyl, isoxazolyl, quinolyl, thiazolyl, carbazolyl, thiadiazolyl, benzotriazolyl, benzothiazolyl, and benzimidazolyl optionally substituted with 1 to 3 substituents selected from acetyl, alkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, phenyl, and phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF3;
• R2 is benzoxazolyl or benzothiazolyl optionally substituted with 1 to 3 substituents selected from acetyl, alkyl, hydroxy, alkoxy, halogen, halogen substituted alkyl, phenyl, and phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF3:
• X1 is a covalent bond, or —(CR15R16)p—, in which R15 and R16 are independently hydrogen, hydroxy, lower alkyl, or —C(O)OR17, in which R17 is hydrogen, lower alkyl, phenyl, or phenyl substituted with alkyl, alkoxy, hydroxy, halogen, or CF3, and p is 1, 2 or 3;
• with the proviso that when p is 1, R15 and R16 cannot be hydroxy;
• R21 is hydrogen or lower alkyl;
• T is oxygen or sulfur;
• Y and Z are —(CR18R19)q— and q at each occurrence is 1, 2 or 3, in which R18 and R19 at each occurrence is hydrogen or lower alkyl;
• and
• R3, R4, R5, R6, R7, R8, R9, and R10 at each occurrence are hydrogen, lower alkyl, or —C(O)R;
• in which R is —OR11 or —NR11R12, where R11 and R12 are hydrogen or lower alkyl;
• or
• R3 and R4, R5 and R6, R7 and R8, R9 and R10, when taken together with the carbon to which they are attached, represent carbonyl;
• Q is oxygen, sulfur, or —NR20—, in which R20 is hydrogen or optionally substituted lower alkyl;
• X2 is a covalent bond or —(CR18R19)q—wherein q at each occurrence is 1, 2 or 3, and R18 and R19 at each occurrence is hydrogen or lower alkyl.